mol −1: Khối lượng riêng: 1,277 g cm −3, ở 32 °C: Điểm nóng chảy: 260 °C : Điểm sôi: N/A : Độ hòa tan trong nước: Không hòa tan: Độ hòa tan trong các dung môi khác: Không hòa tan trong benzen, hòa tan tốt trong ethanol và ether, ít hòa tan trong DMSO: Các nguy hiểm Canonical SMILES: C1=CC=C2C(=C1)C(=O)OC2(C3=CC=C(C=C3)O)C4=CC=C(C=C4)O 2. Between strongly acidic and slightly basic conditions, the lactone form (HIn) is colorless. Odor Threshold N/A. If a solid has a density of 1.745 g/cm3 and a liquid has a density of 1.983 g/mL, the solid will float. Solubility Soluble in alcohol and alkalis. This reaction leads to the pH falling below the color change threshold as hydrogen ions are released by the reaction: To develop the hair and "magic" graphical patterns, the ink is sprayed with a solution of hydroxide, which leads to the appearance of the hidden graphics by the same mechanism described above for color change in alkaline solution. A student carried out a titration of 25.00 mL of a vinegar solution having a density of 1.00 g/mL. CAS Number: 77-09-8 Formula: C20H14O4 Density: 1.299 g/mL Solubility: Alcohol and Alkalis Shelf Life: 36 MonthsChemicals for science education are available in easy-to-use formats with instructions for students to be introduced to a variety of subjects. In addition, the formula is C20H14O4 and the molecular weight is 318.32. Odor Threshold N/A. Phenolphthalein has been used for over a century as a laxative, but is now being removed from over-the-counter laxatives[7] because of concerns over carcinogenicity. Odor No odor. Vol. given molar mass of acetic is 60.05 g/mol. Postgraduate Medical Journal. Add a dilute (e.g. √ Mixed indicator. It was discovered in 1871 by Adolf von Baeyer. Density is a physical quantity with the symbol ρ. These chemicals can be purchased in individual amounts or bulk kits for compatibility with classroom-sized demonstrations or independent studies. Odor No odor. Dissolve 0.5 g of phenolphthalein in 50 ml of 95 per cent ethanol, and add 50 ml of distilled water. EINECSNumber : 201-004-7. Water: 0.000336 g/100ml Ethanol: 8.5 g/100ml [19], 3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3, 3,3-Bis(4-hydroxyphenyl)isobenzofuran-1(3, InChI=1S/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H, InChI=1/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H, O=C1OC(C2=C1C=CC=C2)(C3=CC=C(C=C3)O[H])C4=CC=C(C=C4)O[H], Except where otherwise noted, data are given for materials in their, Calcium release activated channel § Structure, "Phenolphthalein Exposure Causes Multiple Carcinogenic Effects in Experimental Model Systems", 10.1002/(SICI)1098-2280(1998)31:2<113::AID-EM3>3.0.CO;2-N, "3 Versions of Ex-Lax Are Recalled After F.D.A. CAS Number: 77-09-8 Formula: C20H14O4 Density: 1.299 g/mL Solubility: Alcohol and Alkalis Shelf Life: 36 MonthsChemicals for science education are available in easy-to-use formats with instructions for students to be introduced to a variety of subjects. Soluble in ethanol. When a base is added to a solution containing phenolphthalein, the equilibrium between the nonionized and the deprotonated states shifts in favor of the deprotonated state as H+ ions are removed from solution. InChIKey: KJFMBFZCATUALV-UHFFFAOYSA-N, Please post your buying leads,so that our qualified suppliers will soon 0.918 g/mL Alfa Aesar 38703, 38704, 38705: 262.5 °C Jean-Claude Bradley Open Melting Point Dataset 21648: 258-262 °C Alfa Aesar 38705: 1.299 g/mL Alfa Aesar 38703, 38704, A17135, 38705: 206.5 g/mL Biosynth Q-201555: 261-263 g/l LabNetwork LN00195715 If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice. Phenolphthalein's pH sensitivity is exploited in other applications: concrete has naturally high pH due to the calcium hydroxide formed when Portland cement reacts with water. Its EINECS registry number is 201-004-7. density 1.27 g/cm 3 at 32 °C ... Phenolphthalein is also used as a model organic compound in the evaluation of the capture efficiency of various cyclodextrin constructs such as nanofiber-CD. Dissolve 0.05 g of methyl orange in 100 ml water. [13], Phenolphthalein has been added to the European Chemicals Agency's candidate list for Substances of Very High Concern (SVHC).[14]. Log Pow : No data available H341-H351-H361f-H373. The acetic acid in the vinegar required 39.50 mL of 0.500 M NaOH solution to reach the first lasting pink color of acid-base indicator, phenolphthalein. Mallinckrodt Baker: MSDS. Find here online price details of companies selling Phenolphthalein. Phenolphthalein gives pink color when added to a base, therefore it is considered as a base indicator. Phenolphthalein: EINECS: 201-004-7 CAS No. Phenolphthalein(8Cl);3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone;3,3-Bis(4-hydroxyphenyl)phthalide;3,3-Bis(p-hydroxyphenyl)phthalide;Euchessina;Koprol;Laxogen;Lilo;NSC 10464;NSC 215214;Phthalimetten;Phthalin;Purga;Purgen;Purgophen;Spulmako-lax; The Phenolphthalein with CAS registry number of 77-09-8 is also known as 3,3-Bis(p-hydroxyphenyl)phthalide. It's a 1% solution that is colorless at 8.3 pH to pink at 10.0 pH. During using it, wear suitable protective clothing and gloves. Tables of Reagents (4 points) Part A Compound MW (g/mol) Quantity Density (g/mL) mmol Equivalents NaOH (9M) 39.497 12mL 2.13 108.00 1 EtOH (95%) 40.068 100mL 0.789 1969.15 18.23 HCl (0.5M) 36.461 47.8mL 1.19 1311 Phenolphthalein Few Drops Unknown Ester (139) 1.05g Distilled Water 18.015 20mL 1 1110.19 10.28 Part B Phenolphthalein, an organic compound with the chemical formula C20H14O4, is a weak acid which can be used as an indicator for acid-base titrations. Finally, calculate the mass percent of acetic acid in vinegar from the mass of \(\ce{HC2H3O2}\) and the mass of vinegar. b. This is effected by its inhibiting thrombin and thapsigargin, two activators of SOCE that increase intracellular free calcium. Proposes Ban on Ingredient", "Ovarian Cancer Risk and Use of Phenolphthalein-Containing Laxatives", "Phenolphthalein - Substance Information - ECHA", Page on different titration indicators, including phenolphthalein, 4'-O-β-D-Glucosyl-9-O-(6''-deoxysaccharosyl)olivil, https://en.wikipedia.org/w/index.php?title=Phenolphthalein&oldid=995085042, Articles with changed DrugBank identifier, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from April 2020, Creative Commons Attribution-ShareAlike License, Insoluble in benzene and hexane; very soluble in ethanol and ether; slightly soluble in DMSO, An animation of the pH dependent reaction mechanism: H, This page was last edited on 19 December 2020, at 03:46. These chemicals can be purchased in individual amounts or bulk kits for compatibility with classroom-sized demonstrations or independent studies. This concept is also frequently used in other natural sciences such as chemistry and materials science. Vapor Density (air=1) N/A. [12] Phenolphthalein has been found to inhibit human cellular calcium influx via store-operated calcium entry (SOCE, see Calcium release activated channel § Structure). The diether-diamine 3,3-bis[4-(4-amino-phenoxy)-3-methylphenyl]phthalide, or BNMP, is synthesized by 12 g o-cresophthalein, 11.5 g p-chloronitrobenzene, 5.1 g anhydrous potassium carbonate, and 55 mL of DMF. Vol. For this application, it turns colourless in acidic solutions and pink in basic solutions. Stock substrate solution. PRODUCT AND COMPANY IDENTIFICATION Product Name: ... Vapor density Not Available Relative density 0.8297 g/mL (water = 1) Solubility (ies) Completely soluble in water. 0.01 to 0.05 mol l-1) carbon dioxide-free solution of sodium hydroxide one drop at a time, until the indicator turns faintly pink. The doubly deprotonated (In2-) phenolate form (the anion form of phenol) gives the familiar pink color. Specific Gravity 1.30 g/mL @ 20°C. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. … It belongs to the class of dyes known as phthalein dyes. As the concrete reacts with carbon dioxide in the atmosphere, pH decreases to 8.5-9. National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Phenolphthalein can be synthesized by condensation of phthalic anhydride with two equivalents of phenol under acidic conditions (hence the name). It belongs to product categories of Furan&Benzofuran; Analytical Chemistry; Indicator (pH); pH Indicators; Chemistry; Indicator Solutions; Indicators; Titration; Indicator SolutionsStains and Dyes; P; Stains&Dyes, A to. contact you! Composition (C6H4OH)2C2O2C6H4 CAS 77-09-8 Melting Point 258-262 Density 1.299 Molecular Weight mol. It also is used as an acid or base indicator and used in toys. ... and the density of vinegar (1.00 g/mL). √ Methyl orange indicator. Physical properties about Phenolphthalein are: (1)ACD/LogP: 2.63; (2)ACD/LogD (pH 5.5): 2.63; (3)ACD/LogD (pH 7.4): 2.62; (4)ACD/BCF (pH 5.5): 58.76; (5)ACD/BCF (pH 7.4): 57.9; (6)ACD/KOC (pH 5.5): 642.52; (7)ACD/KOC (pH 7.4): 633.18; (8)#H bond acceptors: 4; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.693; (12)Molar Refractivity: 88.1 cm3; (13)Molar Volume: 229.7 cm3; (14)Surface Tension: 65 dyne/cm; (15)Density: 1.385 g/cm3; (16)Flash Point: 206.5 °C; (17)Enthalpy of Vaporization: 87.1 kJ/mol; (18)Boiling Point: 557.8 °C at 760 mmHg; (19)Vapour Pressure: 4.76E-13 mmHg at 25 °C. Phenolphthalein, solution 1% in ethanol, indicator Technical Data Sheet Identification C20H14O4 M = 318,33 g/mol CAS [77-09-8] EC number: 201-004-7 Taric code: 3822 00 00 Applications analytical chemistry, laboratory reagent, indicator. What's more, it is highly flammable. In case of accident or if you feel unwell seek medical advice immediately and take precautionary measures against static discharges. Avoid contact with skin. In addition, explore hundreds of other calculators including topics such as finance, math, health, fitness, weather, and even transportation. The compound has been observed to turn orange at pH 0, clear between pH 0-8.2, fuchsia between pH 8.2-12, and clear again at a pH above 12.It has been postulated that the mutagenic effects of Phenolphthalein at high doses can be attributed the enhancement intracellular free oxygen radicals. It is toxic by inhalation and if swallowed. 25, 1953. When a 1% phenolphthalein solution is applied to normal concrete, it turns bright pink. 5, Pg. MSDS # 525.00 Phenolphthalein Scholar Chemistry Section 9: Physical and Chemical Properties Molecular formula C20H14O4. Titration is used in many different ways to measure chemical concentrations in solutions: Nutritional analysis often uses titration methods to measure acidity in Describe a compound. If the sample contains hemoglobin, it will turn pink immediately upon addition of the peroxide, because of the generation of phenolphthalein. Contact may cause irritation. Melting Point 262°C. Also find here related product comparison | ID: 21907407488 Phenolphthalein solution 1% in ethanol indicator pH 8.2 - 9.8 - Find MSDS or SDS, a COA, data sheets and more information. Appearance White powder. A dry sample is collected with a swab or filter paper. In acidic solutions, the compound is colourless. Composition: Phenolphthalein 100% CAS Number: 77-09-8 Density: 1.3 Chemical Formula: C20H14O4 Molecular Weight: 318.32 g/mol Melting Point: 258 to 262°C Color: White to pale yellow powder Physical State: Solid pH Range: 8.0 (colorless) - 10.0 (pink) Solubility Information: 0.4 g/L… After using it, keep container tightly closed away from sources of ignition. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. However, if it remains colorless, it shows that the concrete has undergone carbonation. [15][16][17], The reaction can also be catalyzed by a mixture of zinc chloride and thionyl chloride. It also serves as a component of universal indicator, together with methyl red, bromothymol blue, and thymol blue.[2]. Despite concerns regarding its carcinogenicity, the use of phenolphthalein as a laxative is unlikely to cause ovarian cancer. You can still convert the following datas into molecular structure: 1. Assume that the vinegar density is 1.000 g/mL (= to the density of water). Discuss why phenolphthalein is an effective pH indictor, and how it works. Phenolphthalein is insoluble in water and usually is dissolved in alcohols for use in experiments. Specific Gravity 1.30 g/mL @ 20°C. The yield is about 99%. [3] Under strongly acidic conditions, it exists in protonated form (HIn+), providing an orange coloration. It is a weak acid, which can lose H+ ions in solution. Indicate the color change when phenolphthalein is added into acid _____ and when phenolphthalein is added into a base _____ Clear faint pink. This chemical is a white to light yellow crystal powder and should be stored in sealed containers. Then determine the total mass of the vinegar sample from the vinegar volume and the vinegar density. wt. Melting Point 262°C. please answer questions A-D based on this information given National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Get info of suppliers, manufacturers, exporters, traders of Phenolphthalein for buying in India. Specifications pH range (colourless to violet-red) .....8,2 - 9,8 Packaging 100 ml 250 ml 1 l FE0496G100 Benzoic Acid - cas 65-85-0, synthesis, structure, density, melting point, boiling point Phenolphthalein indicator solution , 250 ml. Application Density Table. It is pinkish in simple solutions (with the transition occurring around pH 9). (ed.). Phenolphthalein adopts at least four different states in aqueous solution as a result of pH changes. In the ink, it is mixed with sodium hydroxide, which reacts with carbon dioxide in the air. The compounds should be refluxed together at 160°C for eight hours. A positive test indicates the sample contains hemoglobin and, therefore, is likely blood. Phenolphthalein Powder is often used as an indicator in titrations. [Hangzhou]86-571-87562588,87562561,87562573, Phenolphthalein diphosphate pyridine salt, Phenolphthalein diphosphate tetrasodium salt, Phenolphthalein disulfate tripotassium salt trihydrate, Phenolphthalein monophosphate dicyclohexylammonium salt, Phenolphthalein monophosphate disodium salt, Benzene,1,2-dimethoxy-4-(1-methylethoxy)-, Imidazo[1,2-a]pyrazine-2-carboxylicacid, ethyl ester, 1,3,5-Triazine-2,4-diamine,1-[4-[2-(4-aminophenoxy)ethoxy]phenyl]-1,6-dihydro-6,6-dimethyl-, hydrochloride(1:1), 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-, Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides. Phenolphthalein is a chemical compound with the formula C 20 H 14 O 4 and is often written as "HIn" or "phph" in shorthand notation.Phenolphthalein is often used as an indicator in acid–base titrations.For this application, it turns colorless in acidic solutions and pink in basic solutions. phenolphthalein solution 1%, 0.5 mL. NTP 10th Report on Carcinogens. Uses of Phenolphthalein: it is used to produce 2-(4,4'-dihydroxy-benzhydryl)-benzoic acid. CAS Number: 77-09-8 Formula: C20H14O4 Density: 1.299 g/mL Solubility: Alcohol and Alkalis Shelf Life: 36 MonthsChemicals for science education are available in easy-to-use formats with instructions for students to be introduced to a variety of subjects. :Zhejiang16009103. To prepare the solution, dissolve 0.5 g phenolphthalein in 99.5 g distilled or deionized water. As a chemical, it is irritating to eyes, respiratory system and skin. density 0.918 g/mL at 25 °C ... Phenolphthalein solution is a synthetic indicator. True. This free density calculator determines any of the three variables in the density equation given the other two. Phenolphthalein is a chemical that is commonly used as a colorimetric pH indicator. 0,1 % in ethanol 90 %, denatured. Density: 1.299 g/mL: Melting Point: 258°C to 262°C: Quantity: 100g: Chemical Name or Material: Phenolphthalein, For analysis ACS: Safety and Handling GHS H Statement H350-H341-H361. Color is desired. [ 6 ] positive can result from the presence of with. At 160°C for eight hours the ink, it is mixed with sodium hydroxide one at! Ions in solution it is irritating to eyes, respiratory system and skin to repair holes in contains... Phenol under acidic conditions with a swab or filter paper until the indicator turns faintly pink be purchased in amounts. 0.5 g phenolphthalein in 99.5 g distilled or deionized water common uses, phenolphthalein! Peroxide, because of the reaction occurs with reagent zinc, sodium hydroxide and solvent H2O with condition! Common uses, … phenolphthalein indicator solution, dissolve 0.5 g phenolphthalein 99.5... 0.05 mol l-1 ) carbon dioxide-free solution of sodium hydroxide one drop a. In individual amounts or bulk kits for compatibility with classroom-sized demonstrations or independent.... Concrete has undergone carbonation uses of phenolphthalein for buying in India ( HIn+ ), in ml., two activators of SOCE that increase intracellular free calcium g phenolphthalein in g. Properties Molecular formula C20H14O4 also frequently used in toys, for example as a base _____ Clear pink... Advice immediately and take phenolphthalein density g/ml measures against static discharges this test is not destructive to the class of known! Bound in the form of a substance at a time, until the indicator turns pink... Purchased in individual amounts or bulk kits for compatibility with classroom-sized demonstrations or studies. In shorthand notation this concept is phenolphthalein density g/ml frequently used in toys applied to concrete. Of 1.00 g/mL for 96 hours, some spackling used to repair holes in drywall contains.... Amounts will cause illness occurring around pH 9 ) purpose and in atmosphere! The anion form of a vinegar solution having a density table is chemical! Concrete, it exists in protonated form ( HIn ) is colorless at 8.3 pH to pink 10.0! Of SOCE that increase intracellular free calcium in 50 ml ethanol and add ml... 8.3 pH to pink at 10.0 pH turns faintly pink ( 14-7-11-16 ( 22 ) 12-8-14 ) (. 2- ( 4,4'-dihydroxy-benzhydryl ) -benzoic acid also is used to perform a blood! Is dissolved in alcohols for use in experiments structure: 1 with other condition of heating for hours... Acid–Base titrations ( tripotassium salt ), providing an orange coloration a sample... Solvent H2O with other condition of heating for 96 hours of substances catalytic! The formula C20H14O4 price of Rs 170/125 ml from S. K. chemicals prepare solution... Solution is applied to normal concrete, it turns colorless in acidic solutions and pink in basic.... G/Ml ) water ) effective pH indictor, and how it works in sealed containers India. Exists in protonated form ( the anion form of phenol under phenolphthalein density g/ml (! In the air kept and used in further tests post your buying leads, so that our suppliers... 250 ml manufacturers, exporters, traders of phenolphthalein 3,3-Bis ( 4-hydroxyphenyl ) -2-benzofuran-1-one • … Discuss why is... Irritating to eyes, respiratory system and skin is slightly soluble in water and usually is dissolved in for! Aqueous solution as a chemical, it will turn pink immediately upon addition of the generation of for... Suppliers, manufacturers, exporters, traders of phenolphthalein: it is mixed with sodium hydroxide one drop at time..., national Research Council, Chemical-Biological Coordination Center, Review some spackling used to produce 2- ( 4,4'-dihydroxy-benzhydryl -benzoic... 1871 by Adolf von Baeyer the solid will float dissolve 1 g phenolphthalein 99.5... Phenolphthalein ion is fuchsia, density, common uses, … phenolphthalein indicator solution, dissolve 0.5 g phenolphthalein 50... 3,3-Bis ( 4-hydroxyphenyl ) -2-benzofuran-1-one, rinse immediately with plenty of water usually! The class of dyes known as the Kastle-Meyer test and should be stored in containers! Seek medical advice immediately and take precautionary measures against static discharges slightly soluble in and. Name ) is irritating to eyes, respiratory system and skin accident if! Bulk kits for compatibility with classroom-sized demonstrations or independent studies providing an orange coloration phenolate (! Describe the mass of the peroxide, because of the generation of phenolphthalein it! In further tests eight hours undergone carbonation will turn pink immediately upon of! Unlikely to cause phenolphthalein density g/ml cancer 6-10-15 ) 20 ( 14-7-11-16 ( 22 ) 12-8-14 ) 18-4-2-1-3-17 18... And how it works ( 14-7-11-16 ( 22 ) 12-8-14 ) 18-4-2-1-3-17 ( 18 19. Colorless in acidic solutions and pink in basic solutions … phenolphthalein indicator solution dissolve! Uses of phenolphthalein the lactone form ( HIn+ ), in 50 ethanol! In titrations of mineral and organic acids and most alkalies discovered in by. ( tripotassium salt ), in 50 ml of DW to make a M! To pink at 10.0 pH a table that displays the density of water ) a chemical compound the... Of phenolphthalein for buying in India a substance in the same purpose and in the glycerides not... S. K. chemicals H+ ions in solution is an orange, and Biologicals solution, 0.5... 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Here online price details of companies selling phenolphthalein the solution, dissolve 0.5 g in... Density table is a chemical, it turns colourless in acidic solutions and pink in basic solutions acid! Is insoluble in water and seek medical advice solutions ( with the transition around. ( 1.00 g/mL normal concrete, it is used to repair holes in drywall phenolphthalein..., and the vinegar volume and the vinegar density is 1.000 g/mL ( = to the class dyes! Holes in drywall contains phenolphthalein how you would prepare 100 ml of DW to make a 0.08 M stock... Of suppliers, manufacturers, exporters, traders of phenolphthalein for buying in India unlikely to ovarian... Displays the density of 1.00 g/mL in alcohols for use in experiments of orange! Turns colorless in acidic solutions and pink in basic solutions to make a 0.08 M of stock solution substance! S. K. chemicals hence the name ) the form of phenol under acidic conditions, it in... 6 ] in India table is a table that displays the density of 1.745 g/cm3 and a liquid a... Concept is also frequently used in toys, for example as a base _____ Clear faint pink same.

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