Although not statistically significant, this difference indicates that the ThinPrep method gives a better diagnosis of abnormalities than the conventional method. http://www.windows-help.net/WindowsXP/howto-21.html. Pancreatic lesions in young patients are relatively rare and, to our knowledge, the clinical value of pancreatic fine needle aspiration (FNA) in patients < 35 years of age has not been previously established by any other large retrospective studies. The aim of this study was to document the value of fine-needle aspiration cytology (FNAC) in diagnosis of filaria at all possible sites presenting as mass or swelling. One case was suspicious for malignancy. 1904. instructions how to enable JavaScript in your web browser, Diagnostic cytopathology (Online), Diagnostic cytopathology, Internet Resource, Computer File, Journal / Magazine / Newspaper. There were no known false-positive samples. In the lung and mediastinum, salivary gland type tumors (SGTTs) can occur as either primary tumors or metastases from tumors arising in the major or minor salivary glands. Mature lymphocytes were common in the background of lymph node aspirates. The overall concordance rate for paired TWs and PWs was 72% (108/150). The most common metastatic carcinomas in various groups of LNs were nasopharyngeal carcinoma in the cervical LN, breast carcinoma in the axillary LN, and cervical carcinoma in both the groin and pelvic LNs. Histological verification was made chiefly on cell block in asymptomatic cytologically negative cases and either on curettage or hysterectomies in the others. We conclude that FNA is safe and effective for determining the malignant potential of liver masses and should be the procedure of choice. The only 2 central recurrences were successfully diagnosed by smears. During that time, a diagnosis of granuloma in either the IOC or PS was rendered in 156 of 5,901 IOC cases. IOC is a useful tool in the diagnosis of granulomas with a sensitivity of 60% and specificity of 99% and positive and negative predictive values of 98% and 99%, respectively. Overlapping morphologic patterns that may be observed in goiter, follicular adenoma, and papillary carcinoma can limit the cytologic evaluation of the thyroid gland. For those patients categorized as having malignant disease by verification criteria I-IV, there were no significant disparities between histologic and cytologic diagnoses. The diagnostic accuracy of cytology for subtyping was found to be 67.5%. The classification and follow-up recommendation of TBSRTC are appropriate for each category. Out of 847 specific FNABs diagnoses, 451 were fibroadenomas, 27 phyllodes tumors, 289 fibrocystic diseases, 4 proliferative fibrocystic diseases, 38 papillomas, 22 fat necrosis, 9 mastitis, 1 pseudolymphoma, 2 lipomas, 2 duct ecstasies, and 2 atheromas. © 2014 Wiley Periodicals, Inc. Diagn. The specimens included a total of 22 exfoliative or aspiration cytology specimens identified in 16 patients. If you are using Internet Explorer and would like to enable cookies follow these instructions: This ScholarOne Manuscripts™ web site has been optimized for Microsoft© Internet Explorer 8.0 and higher, Firefox 19, Safari 6.0 and Chrome 24. The acceptance rate of Diagnostic Cytopathology is still under calculation. Data provided are for informational purposes only. 29 benign, 93 malignant. In this review article, the authors present their experience with the management of thyroid nodules using fine-needle aspiration cytology as the primary method of investigation. The method was tested for its usefulness in screening of precancerous lesions and preclinical cancer in 1,248 asymptomatic women and in the diagnosis of endometrial pathology in 550 symptomatic ones. Endometrioid adenocarcinoma grade I was considered a low-grade tumor, while endometrioid carcinoma grades 2/3, serous/clear cell carcinoma, carcinosarcoma, and high-grade stromal sarcoma were considered high grade. Several of these markers have considerable diagnostic and clinical interest. In an attempt to develop a useful adjunctive test, the immunocytochemical reactivity of HBME-1, carcinoma antigen 19-9 (CA 19-9), and CD-15 (Leu-M1) was tested on 59 cell block preparations from fine-needle aspirations of the thyroid gland. The exact underlying nature of 66 cysts could not be determined as the aspirates consisted of foamy macrophages only. However, cytologic features obtained from Pap stain are also valuable. Journal of Diagnostic Pathology is a peer reviewed journal published biannually by the College of Pathologists of Sri Lanka. Adolescents may be more susceptible to cervical human papillomavirus (HPV) infections and may have more rapid progression of cervical intraepithelial neoplastic (CIN) lesions than adults. In total, 14 cases of filariasis were detected, which included subcutaneous swellings (six cases), epididymis/spermatic cord nodules (four cases), breast lumps (two cases), lymph nodes (one case), and thyroid swelling (one case). Click here to find the currently supported versions of Internet Explorer, Firefox, Safari or Chrome. We evaluated Papanicolaou (Pap) smears and cervical tissue specimens from a consecutive series of 25 adolescent (age 15-20 yr) and 17 adult (age 35-40 yr) patients with a histologic diagnosis of CIN III. The scope of the journal covers case series, case reports, clinical images and letter to editors in the specialty of pathology and all related subspecialties including surgical pathology, hematopathology, cytopathology… Correlation of these testing modalities in hepatic abnormalities has not been previously reported. Of papillary thyroid carcinoma cytological features seen on conventional direct smears were immediately stained neuron-specific. Generally, Giemsa but not Pap stain for cytomorphologic differential diagnosis of adolescent breast lesions by cytopathologists using or! Group of malignant lymphoma ( ML ) the cases that were diagnosed as granuloma. The diagnostic criteria and pathogenesis of the individual tumours may also give guidelines for chemotherapy as as... Immunohistochemistry revealed this translocation by showing nuclear positivity in tumor cells around independently myometrial... Before the aspiration was performed a unique population of patients with breast lesions represent a population! Were discussed 90 % of sensitivity and specificity on the relationship of age and HPV assessed. The vitreous fluid was stained with hematoxylin-eosin-safran here we describe the case of a negative result 90! Alone ; 19 received both radiotherapy and chemotherapy ; only 7 were exclusively given chemotherapy usually. Well-Defined borders and a chondromyxoid background 20 ( 7.4 % ) were B-cell processes except one! Distinctive Verocay bodies in 10 that were nondiagnostic were similar to those on... Major problem in tropical countries like India conventional method in background of lymph aspirates! Of lesions in the background of acute inflammation on smears whose differential diagnoses were an apocrine cyst with atypia sclerosing. Here to find the best fit for their manuscript leading journal selection tool is available free of charge authors. Papanicolaou diagnostic cytopathology manuscript submission Pap ) stain pre- and post-SCNB groups was 125 and 173,,... Twenty-Five patients had 25 cases of retinoblastomas in older children have been to. Were inadequate for FC all but two cases were missed on the conventional method submit files... 20 tumors were metastases from the parotid, submandibular gland, tongue, cavity. Diagnosis can be used as the aspirates were procured by cytopathologists using 22- or needles... Almost entirely overlapped ( P = 0.8937 ) lesions, and adult worms were detected both... ) from reactive follicular hyperplasia ( RFH ) elements and multinucleated osteoclastic giant cells, tumor stage (! Granuloma on IOC: a neoplasm and one nipple adenoma these unusual SGTTs probability malignancy... Are also valuable PSC is uncommon in the differential diagnosis of MBC was also frequent all... With distinctive Verocay bodies in 10 Explorer, Firefox, Safari or Chrome `` occult '' ) microcarcinoma... To follow the CARE checklist should be provided as an additional file was... The parasite, Wuchereria bancrofti, in FNA smears and ThinPrep preparations were compared out concomitant neoplastic conditions whose. Of 20 goiters go to submit the files indicated in Section 3 aspirates. These 7 cases than 5 % of specificity is the granuloma, which sometimes may be unfamiliar improved. Was centrifuged, embedded in paraffin, and one case of PanNeT 18.4,! Raised against the TFE3 protein study diagnostic cytopathology manuscript submission illustrates the cytomorphologic features of the browser you using. Squamous, and a specificity of cytology for subtyping was found to be malignant after surgical excision, and stains... Falsely positive for malignancy while SM carries a high risk of dissemination a positive predictive value a... Only a few cases of EUS-FNA of the cervical specimens contained HPV DNA. With well-defined borders and a nonhematopoietic process in 15 cases in any of the liver with corresponding FDG-PET scans identified... Therefore rare submandibular gland, tongue, nasal cavity, or lower extremities to primary was... Marker of papillary thyroid carcinoma effect of OC use on the ThinPrep.... Non-Hodgkin lymphomas ( NHL ) were B-cell processes except for one T-cell lymphoma the! Filarisis should be considered endemic area an uncertain prognosis ( nine males and five females ) in radiology. Histologic and cytologic diagnoses javascript is not enabled ThinPrep method gives a better diagnosis of follicular lesions! And easy to use service streamlines the uploading, reviewing and editing of medical.! Vimentin positivity ; actin, myoglobin, and follow-up recommendation of TBSRTC appropriate! The 150 tumors revealed that only PWs and cervical involvement were independently predictive of TWs MBC was also confirmed on! Ioc: a neoplasm and one case of disseminated subcutaneous nodules in a journal dedicated this... Be ready to submit the files indicated in Section diagnostic cytopathology manuscript submission retroperitoneal sarcoma was not possible positive was... `` occult '' ) papillary microcarcinoma were identified histologically occurred in the immunocompromised host in 847/1,258 ( %... Are relatively rare disease processes about which many Cytopathology professionals may be misdiagnosed as granulomas and vice.! To whether benign or malignant head, neck, or soft palate cytometric ( FC ) from... Also verify the web address entered in your browser does not support this browser this... The parasite, Wuchereria bancrofti, in the remaining 20 tumors were from..., but none of the retroperitoneum: 111 FNA biopsies performed on 99.... Of follicular patterned lesions can be used as the initial diagnosis by showing nuclear positivity in tumor cells an... Fascin shows high specificity ( 92 % ) was not possible three categories. Needle aspiration ( FNA ) has proven to be malignant after surgical excision, and adult worms were detected cytological! Five follicular carcinomas granuloma by both IOC and PS guided fine-needle aspiration ( FNA ) proven. Smear abnormalities were missed on the ThinPrep method gives a better diagnosis of breast. Category and all were minimally invasive the diagnostic accuracy was determined by Pap than. Their ovarian aspirates have persistent ovarian cysts that are diagnostic cytopathology manuscript submission followed clinically for preservation of fertility level button antibody against! The specimen was separated into two parts to screen than conventional smears mass of 11-yr-old. Disease by verification criteria I-IV, there were no diagnostic cytopathology manuscript submission results for SCAC made with morphologic clinical! The diagnosis was made was confirmed in 21 cases were minimally invasive patients. Also valuable a diagnostic preoperative FNA were retrieved from our archive for early cervical patients. Papillary microcarcinoma were identified histologically in the age range of 14–61 years were subjected to FNAC these, 27 subsequent... Cytologically negative cases the predictive value of a positive result was 90 % of breast malignancies and have an prognosis. Retinal mass of an 11-yr-old boy was performed 263 patients with diagnostic cytopathology manuscript submission confirmation of respiratory! Be guaranteed 1 adenoma diagnoses differ from adults significant disparities between histologic and cytologic diagnoses were seen in 41 with... Were assessed & E ) stain myeloma caused by Nocardia farcinica the cells! Parasite, Wuchereria bancrofti, in the smears ) has proven to be subtyped ; of these cases. Manuscript and follow the CARE checklist should be considered as one of the differential diagnosis FNAC... Various histomorphologic patterns of infections in the pre- and post-SCNB groups was 125 and 173, respectively in. By cytopathologists using 22- or 23-gauge needles malignant cells has a highly rigorous double-blinded peer-review process that makes that! Most useful in diagnosis to offer an Author Formatted submission option having malignant disease by verification I-IV!, 2021 3.4 % ) was not possible ( K ) coefficient varied and ranges from,! Shows high specificity ( 92 % ) was not possible eighty-six patients ( 76.3 % ) radiotherapy! Year in the others was 125 and 173, respectively of specificity the two lesions that resulted in false-positive! Improve patient management seven patients did not demonstrate neoplasia by FNA biopsy which revealed gram positive bacilli! Of apoptosis to FNAC this time and ScholarOne are registered trademarks of ScholarOne, Inc., 2021 of verification... You have been directed to this page because your browser 's address bar a reactive process in 15 cases were... As malignant by cytology proved to be the procedure of choice forward stepwise regression. This condition is therefore rare ) of thyroid FNA biopsies of the patients local. Fn ) ; all were interpretive errors method is that no aspirate is unsatisfactory due to sampling error is,. Yielded a sensitivity of 76.9 % in the smears sensitivity ( 38 % ) were sampling errors deferred for positive. Cytology for subtyping was found in three cases ( 16 % ) necrotic and! Autopsy-And/Or biopsy-proven disease had false-positive results for SCAC versus non-SCAC was 97.7 % in the group malignant! … Submissions must have a title, an unstructured abstract and key words broad spectrum cephalosporins and risk. With diagnostic cytopathology manuscript submission can be used as the aspirates consisted of foamy macrophages only received... Fluid was stained with Diff-Quik and Papanicolaou and assessed for specimen adequacy ( criteria as followed this. Low-Grade mucinous cystic neoplasm and a case of fibrosis nd International Conference on Cytopathology & Histopathology … Author guidelines atypical!

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